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Jennifer Kehlet Barton,
Ph.D.
Education: 1988 B.S.,
Electrical Engineering, The University of Texas at Austin 1993 M.S.,
Electrical Engineering, The University of California, Irvine 1998 Ph.D.,
Biomedical Engineering, The University of Texas at Austin Positions: 1988-1994 McDonnell Douglas Aerospace (now Boeing Corp.),
Huntington Beach, CA. Engineer/Scientist Specialist, International Space
Station 1994-1998 The University of Texas, Austin, TX. Research
Assistant, Biomedical Engineering Program 1998-pres. The University of
Arizona, Tucson, AZ. Assistant Professor (1998-2003), Associate Professor
(2003-pres.) Biomedical Engineering (primary appointment), Electrical and
Computer Engineering Department, College of Optical Sciences, Arizona Cancer
Center, Bio5 Institute 2006 Visiting
Scientist, Beckman Laser Institute, The University of California, Irvine 2007-pres. Chair, Biomedical
Engineering Graduate Interdisciplinary Program, The University of Arizona 2007-pres. Director, Division of
Biomedical Engineering, The University of Arizona Professional
Activities: 2003-2007 National Institutes of Health
Biomedical Imaging Technology (BMIT, formerly DMG) Study Section Charter Member
(3 review sessions per year) Various: Proposal
reviewer for: National Science Foundation, National Institutes of Health ad hoc
and site visit committees, California Breast Cancer Research Program,
California Tobacco-Related Disease Research Program, Philip Morris External
Research Program, The University of Arizona Small Grants Program, Center for
Integration of Medicine and Innovative Technology, Technology Foundation STW
(Dutch Foundation), Connecticut Innovations, Science and Technology Center
Ukraine Various: Journal
Reviewer for: Annals of Biomedical Engineering, Applied Optics, Dermatological
Surgery, Expert Reviews in Dermatology, IEEE Transactions on Biomedical
Engineering, IEEE Transactions on Education, IEEE Transactions on Medical
Imaging, Journal of Biomedical Optics, Journal of Lightwave Technology, Journal
of the Optical Society of America, Lasers in Surgery and Medicine, Medical
Physics, Microcirculation, Nature Photonics, Optics Express, Optics and Lasers
in Engineering, Optics Letters, Physics in Medicine and Biology, Technology in
Cancer Research and Treatment Societies: American Society for
Laser Medicine and Surgery: Fellow; 2004-2007 Board of Directors; 2004-pres.
Research and Development Committee; 2005-2006 Ethics Committee; 2002,3,4,5,6,7
Session chair Annual meeting Biomedical Engineering
Society: Member; 2000-pres. Faculty Advisor UA student chapter; 2003 Session
chair for Annual Meeting Institute of
Electrical and Electronic Engineers: Member; 2004 Committee IEEE LEOS annual
meeting Optical Society of
America: Member; 2003 Optics in Biology and Medicine vice-chair; 2003, 2005
Session chair annual meeting SPIE: Fellow; 2001 Co-chair,
SPIE Opto-Southwest, Conference on Optical Imaging in Medicine; 2003,4,5,6,7,8
Session chair and program committee, Photonics West; 2005-pres. Co-chair
International Biomedical Optics Society; 2005,7 Session chair and program
committee European Conferences on Biomedical Optics; 2006 Women in Optics
Calendar of Days; 2006 Featured in "Your Society" Member Guide; 2006 Essay in
SPIE "50 Years" publication Awards: 1996,1997 NASA/Texas
Space Grant Fellowship 1996,1997 A.D.
Hutchinson/University of Texas Endowment Fellowship 1997 SPIE
D.J. Lovell Scholarship 1998 Research
Paper Award, 18th Ann. Mtg, ASLMS 1999
Award
for Excellence at the Student Interface, College of Engineering and Mines Publications: Peer
Reviewed Articles: Barton JK, Milner TE, Pfefer TJ, Nelson JS,
Welch AJ: Optical low coherence
reflectometry to enhance Monte Carlo modeling of skin. Journal of Biomedical Optics,
2(2):226-234, 1997. Pfefer TJ, Barton JK, Chan EK, Ducros MG, Sorg BS, Welch
AJ: A three dimensional modular
adaptable grid numerical model for light propagation during laser irradiation
of skin tissue. Journal of
Selected Topics in Quantum Electronics, 2(4):934-942, 1997. Wright CHG, Barton JK, Protsenko DE, Rylander HG, Welch
AJ: Anomalous reflectance of
laser-induced retinal lesions.
Journal of Selected Topics in Quantum Electronics, 2(4):1035-1040, 1997. Izatt JA, Kulkarni MD, Yazdanfar S, Barton
JK, Welch AJ: In vivo bidirectional Doppler flow
imaging of picoliter blood volumes using optical coherence tomography. Optics Letters, 22(18):1439-1441, 1997. Choi B, Barton JK, Chan EK, Welch AJ: Imaging of the irradiation of skin with
a clinical CO2 laser system: Implications for laser skin
resurfacing: Lasers in Surgery and
Medicine, 23:185-193, 1998. Barton JK, Pfefer TJ, Welch AJ, Smithies DJ,
Nelson JS, van Gemert MJC: Optical
Monte Carlo modeling of a true port wine stain anatomy. Optics Express 2, 391, 1998. Barton JK, Izatt JA, Welch AJ: Investigating pulsed dye laser-blood
vessel interaction with color Doppler optical coherence tomography. Optics Express 2:251-256, 1998. Barton JK, Izatt JA, Kulkarni MD, Yazdanfar
S, and Welch AJ: Three-dimensional
reconstruction of blood vessels from in vivo color Doppler optical coherence
tomography images. Dermatology,
198:355-361, 1999. Barton JK, Hammer DX, Pfefer TJ, Lund TJ,
Stuck BE, Welch AJ: Simultaneous
irradiation and imaging of cutaneous blood vessels. Lasers in Surgery and Medicine, 24:236-243, 1999. Choi B, Chan EK, Barton
JK, Thomsen SL, Welch AJ: Thermographic and histological evaluation
of laser skin resurfacing scans.
IEEE Journal of Selected Topics in Quantum Electronics, 5:1116-1126,
1999. Vargas G, Chan EK, Barton JK, Rylander HG, Welch AJ: Use of an agent to reduce scattering in
skin. Lasers in Surgery and
Medicine, 24:133-141 1999. Pfefer TJ, Barton JK, Smithies DJ, Milner TE, Nelson JS,
van Gemert MJC, Welch AJ: Modeling
laser treatment of port wine stains with a computer-reconstructed biopsy. Lasers in Surgery and Medicine,
24:151-166, 1999. Barton
JK, Vargas G, Pfefer
TJ, Welch AJ: Laser fluence for
permanent damage of cutaneous blood vessels. Photochemistry and Photobiology, 70:916-920, 1999. Barton JK, Rollins A, Yazdanfar S, Pfefer TJ, Westphal V,
Izatt JA: Photothermal coagulation
of blood vessels: a comparison of high-speed optical coherence tomography and
numerical modeling. Physics in
Medicine and Biology, 46:1665-1678, 2001. Barton
JK, Frangineas G,
Pummer H, Black JF: Cooperative
phenomena in two-pulse, two-color laser photocoagulation of cutaneous blood
vessels. Photochemistry and
Photobiology, Jun;73(6):642-50, 2001. Barton
JK, Popok D, Black
JF: Thermal analysis of blood
undergoing laser photocoagulation.
IEEE Journal of Selected Topics in Quantum Electronics, 7:936-943, 2001. Wong
RC, Yazdanfar S, Izatt JA, Kulkarni M, Barton JK, Welch AJ, Willis J, Sivak MV: Visualization of subsurface blood
vessels by color Doppler-optical coherence tomography in rats: before and after
hemostatic therapy.
Gastrointestinal Endoscopy, 55(1):88-95, 2002. Hansen
KA, Weiss JA, Barton JK: Recruitment of tendon
crimp with applied tensile strain.
Journal of Biomechanical Engineering, 124:72-77, 2002. Rollins
AM, Yazdanfar S, Barton JK, and Izatt JA:
Real-time in vivo color Doppler optical coherence tomography. Journal of Biomedical Optics, 7:123-129, 2002. Gossage
K, Tkaczyk T, Rodriguez J, Barton JK: Texture Analysis of Optical Coherence Tomography Images:
Feasibility for Tissue Classification," Journal of Biomedical Optics 8:570-575,
2003. Loeb
G, Barton JK:
Optical Coherence Tomography for Morphological Imaging of Fruits. Transactions
of the American Society of Agricultural Engineering, 46:1751-1757, 2003. Barton
JK, Gossage KW, Xu
W, Ranger-Moore J, Saboda K, Brooks CA, Duckett LD, Salache SJ, Warneke JA,
Alberts DS: Investigating sundamaged skin and actinic keratosis with optical
coherence tomography: a pilot study. Technology in Cancer Research and
Treatment, 2:525-535, 2003. Tumlinson
AR, Hariri LP, Utzinger U, Barton JK: A miniature endoscope for simultaneous OCT-LIF
measurement. Applied Optics, 43:113-121, 2004. Barton
JK, Guzman F,
Tumlinson AR: Dual modality instrument for simultaneous optical coherence
tomography imaging and fluorescence spectroscopy. Journal of Biomedical Optics,
9:618-623, 2004. Alberding
J, Barton JK,
Wiley EB, Baldwin AL: Onset of pulsatile pressure
causes transiently increased filtration through artery wall, American Journal
of Physiology, Heart Circ. Physiol., 286:H1827-35, 2004. Loo C, Lin A, Hirsch L, Lee M, Barton JK, Halas N, West J,
Drezek R: Nanoshell-enabled photonics-based imaging and therapy of cancer,
Technology in Cancer Research and Treatment, 3:33-40 2004. Scepanovic M, Castillo JE, Barton JK, Mathine D, Kostuk RK, Sato A: Design and processing of high-density single-mode fiber arrays for imaging and parallel interferometer applications, Appl. Opt. 43: 4150-4156, 2004. Brewer M, Utzinger
U, Barton JK, Hoying JB,
Kirkpatrick ND, Brands WR, Davis JR, Hunt K, Stevens SJ, Gmitro AF, Imaging of
the Ovary, Technology in Cancer Research and Treatment, 3: 617-628, 2004. Kariya R, Mathine
DL, Barton JK, Analog CMOS
Circuit Design and Characterization for Optical Coherence Tomography Signal
Processing, IEEE Transactions on Biomedical Engineering, 51:2160-3, 2004. Black JF and Barton
JK, "Chemical and Structural Changes
in Blood Undergoing Laser Photocoagulation," Photochemistry and Photobiology,
80:89-97, 2004. Black JF, Wade N, Barton
JK, "Mechanistic comparison of blood
undergoing laser photocoagulation at 532 and 1,064 nm," Lasers Surg. Med.
36:155-165, 2005. Barton JK, Stromski S, "Flow
measurement without phase information in optical coherence tomography
images," Optics Express, 13:5234-5239, 2005. Alberding JP, Baldwin AL, Barton JK, Wiley E, "Effects of
pulsation frequency and endothelial integrity on enhanced arterial transmural
filtration produced by pulsatile pressure," Am J Physiol Heart Circ Physiol.
289(2):H931-7 2005. Gossage KW, Smith CM,
Kanter EM, Hariri LP, Stone AL, Rodriguez JJ, Williams SK, Barton JK, "Texture analysis of
speckle in optical coherence tomography images of tissue phantoms",
Physics in Medicine and Biology, 51:1563-1575, 2006. Hariri LP, Tumlinson AR, Wade NH, Besselsen D, Utzinger U,
Gerner E, Barton JK, "Endoscopic optical coherence tomography and laser induced
fluorescence spectroscopy in a murine colon cancer model," Lasers in Surgery
and Medicine, 38:305-313, 2006. Xu W, Bonnema GT, Gossage KW, Wade NH, Medford J, Barton JK, "Customized
analog circuit design for fiber based optical coherence microscopy," Review of
Scientific Instruments 77: 016104, 2006. McNally J, Kirkpatrick N, Hariri LP, Tumlinson AR, Besselsen
D, Gerner E, Urs Utzinger U, Barton J., "Task Based Imaging of Colon Cancer in a Mouse Model (ApcMin/+)," Applied Optics, 45: 3049-3062, 2006. Kanter EM, Walker RM, Marion SL, Brewer M, Hoyer PB, Barton
JK, "Dual modality imaging of a novel rat model of ovarian
carcinogenesis," Journal of Biomedical Optics, Vol. 11, 041123, 2006. Agrawal A, Huang S, Wei
A, Lin H, Lee M, Barton JK, Drezek R, Pfefer J, "Quantitative evaluation of optical coherence
tomography signal enhancement with gold nanoshells," Journal of Biomedical
Optics, Vol. 11, 041121, 2006. Tumlinson
AR, Barton JK, Povazay B, Sattman
H, Unterhuber A, Leitgeb RA, Drexler W, "Endoscope-tip interferometer for
ultrahigh resolution frequency domain optical coherence tomography in mouse
colon," Optics Express, 14: 1878-1887, 2006. Xu
W, Mathine DL, Barton JK,
"High-gain differential CMOS transimpedance amplifier with on-chip buried
double junction photodiode," Electronics Letters 42(14):803-5, 2006. Tumlinson AR, Povazay B, Hariri LP, McNally J, Unterhuber A,
Hermann B, Sattmann H, Drexler W, Barton JK, "In vivo
ultrahigh-resolution optical coherence tomography of mouse colon with an
achromatized endoscope," Journal of Biomedical Optics, 11:064003, 2006. Cardinal KO, Bonnema GT, Hofer H, Barton JK, Williams SK,
"Tissue Engineered Vascular Grafts as In Vitro Blood Vessel Mimics to
Evaluate Endothelialization of Intravascular Devices" Tissue Engineering,
12:3431-8, 2006. Luo Y , Castillo J, Arauz L, Barton JK, Kostuk RK, "Coupling
and crosstalk effects in high density fiber imaging," Applied Optics
26:253-261, 2007. Hariri
LP, Tumlinson AR, Wade NH, Besselsen DG, Utzinger U, Gerner EW, Barton JK, "Ex Vivo Optical Coherence
Tomography and Laser-induced Fluorescence Spectroscopy Imaging of Murine
Gastrointestinal Tract," Comparative Medicine, 57 02 04, 2007. Bonnema
GT, Cardinal KO, McNally JB, Williams SK, Barton JK, "Assessment of Blood Vessel Mimics
with Optical Coherence Tomography," Journal of Biomedical Optics, 12:024018,
2007. Troutman
T, Barton JK,
Romanowski M, "Optical Coherence Tomography with Plasmon Resonant Nanorods of
Gold," Optics Letters, 32:1438-1440, 2007. Xu
W, Mathine DL, Barton JK, "Analog CMOS design for optical coherence tomography signal detection
and processing," IEEE Transactions on Biomedical Engineering, accepted. Hariri
LP, Qiu L, Tumlinson AR, Besselsen DG, Gerner EG, Ignatenko N, Povazay B,
Hermann B, Sattmann H, McNally J, Unterhuber, Drexler W, Barton JK, "Serial endoscopy in azoxymethane
treated mice using ultrahigh resolution optical coherence tomography," Cancer
Biology and Therapy, accepted. Luo
Y, Arauz L, Castillo J, Barton JK, Kostuk R, "Parallel Optical Coherence Tomography System"
Applied Optics, accepted. Korde
V, Bonnema G, Xu W, Krishnamurthy C, Ranger-Moore J, Saboda K, Slayton L,
Salasche S, Warneke J, Alberts D, and Barton J, "Using Optical Coherence
Tomography to Evaluate Skin Sun Damage and Precancer", Lasers in Surgery and
Medicine, 39:687-695, 2007. Tumlinson
AR, Hofer B, Winkler A, Povazay B, Drexler W, Barton JK, Inherent homogenous media
dispersion compensation in frequency domain optical coherence tomography by
accurate "k-sampling", in press. Book
Chapters: J.K.
Barton, A. Tumlinson, U. Utzinger, "Combined
Endoscopic Optical Coherence Tomography and Laser Induced Fluorescence," in Handbook
of Optical Coherence Tomography, W.
Drexler and J. Fujimoto, eds. to be published in 2007. Periodical
and other publications: J.A. Izatt, M.D. Kulkarni, K.
Kobayashi, M.V. Sivak, J.K. Barton, and A.J. Welch, "Optical Coherence Tomography for
Biodiagnostics," Optics and Photonics News 8:41-47, 1997. J.K. Barton, "Optical Coherence
Tomography," McGraw-Hill 2000 Yearbook of Science and Technology,
McGraw-Hill, New York, NY, 2000. J.F. Black and J.K. Barton "Two-photon laser techniques for
diagnostic and therapeutic medicine," DOPS-NYT Journal of the Danish Optical
Society, 4:29-33 2001. Full-length Manuscript Conference
Proceedings: E.K. Chan, B. Amini, J.K. Barton, A.J. Welch, S.L. Thomsen, R.C.
Stoneman, L. Esterowitz. "Wavelength dependency of soft tissue coagulation with
a tunable cw laser," proc. SPIE, 2581, p. 102-113, 1996. J.K. Barton, J.A. Izatt, M.D. Kulkarni, A.J.
Welch, "Three-dimensional reconstruction of rat dermal blood vessels in
vivo," proc. SPIE, v. 2970, p. 266-275, 1997. A.J. Welch, E.K. Chan, J.K.
Barton, B. Choi, S.
L. Thomsen. "Infrared imaging of CO2 laser resurfacing," proc. SPIE, 2970, p. 305-311, 1997. T.J. Pfefer, J.K. Barton, E.K. Chan, M.G. Ducros, B.S. Sorg,
T.E. Milner, J.S. Nelson, A.J. Welch. "Adaptable three-dimensional Monte Carlo
modeling of imaged blood vessels in skin," proc. SPIE, 2975 p. 2-13, 1997. J.K. Barton J.A. Izatt, A.J. Welch,
"Investigating laser-blood vessel interaction with color Doppler optical
coherence tomography." proc. SPIE, 3251 p. 102-113, 1998. S. Yazdanfar, M.D. Kulkarni, R.C.K.
Wong, M.V. Sivak, J. Willis, J.K. Barton, A.J. Welch, J.A. Izatt, "Diagnostic blood flow
monitoring during therapeutic interceptions using color Doppler optical
coherence tomography," proc. SPIE, 3251 p. 126-132, 1998. B. Choi, J.K. Barton, E.K. Chan, S.L. Thomsen, A.J.
Welch, "Infrared imaging of CO2 laser ablation: Implications for laser
skin resurfacing," proc. SPIE, 3245 p. 344-355, 1998. T.J. Pfefer, J.K. Barton, D. Smithies, T.E. Milner, M.J.C.
van Gemert, J.S. Nelson, A.J. Welch, "Laser Treatment of Port Wine Stains:
Three-Dimensional Simulation Using Biopsy-Defined Geometry in an
Optical-Thermal Model," proc. SPIE, 3245 p. 322-333, 1998. G. Vargas, J.K. Barton, B. Choi, J.A. Izatt, A.J. Welch,
"Assessing vessel damage with color Doppler optical coherence
tomography," proc. SPIE, 3598, p.185-194, 1999. J.K. Barton, D.B. Dal Ponte, S/K.
Williams, B.K. Ford, M.R. Descour, "Imaging vascular implants with optical
coherence tomography," proc. SPIE Vol. 3915, p. 229-236, 2000. K.A. Hansen, J.K.
Barton,
J.A. Weiss, Optical coherence tomography imaging of collagenous tissue
microstructure proc. SPIE Vol. 3914, p. 581-587, 2000. G. Vargas, J.K. Barton, A.J. Welch, "Selective
photocoagulation of cutaneous blood vessels with evaluation of vessel damage by
color Doppler optical coherence tomography," proc. SPIE 3907:136-142, 2000. J.K. Barton, A.M. Rollins, S.
Yazdanfar, T.J. Pfefer, V. Westphal, J.A. Izatt, "Optical-thermal model
verification by high-speed optical coherence tomography," proc. SPIE Vol. 4251, p. 174-182,
2001. F. Guzman, J.K.
Barton,
"Dual OCT/spectroscopy system for identification of vascular pathology," proc.
SPIE
Vol. 4244, p. 413-418, 2001. J.F. Black, J.K.
Barton,
"Cooperative phenomena in two-pulse two-color laser photocoagulation of
cutaneous blood vessels, proc. SPIE vol. 4244, p. 13-24, 2001. J.K. Barton, S.J. Loui, J.F. Black, "Optical
and magnetic resonance changes in photothermally coagulating blood," proc.
SPIE Vol.
4609:10-19, 2002. T.S. Tkaczyk, K.W.
Gossage, J.K. Barton, "Speckle image properties in optical coherence
tomography," proc. SPIE Vol. 4619, p. 59-70, 2002. F. Guzman, J.K.
Barton,
"Catheter-based instrument for simultaneous OCT imaging and fluorescence
spectroscopy," proc. SPIE Vol. 4609, p. 430-437, 2002. K.W. Gossage, T.S.
Tkaczyk, J.K. Barton, "Using optical coherence tomography to evaluate glaucoma
implant healing response in rabbit eyes," proc. SPIE Vol. 4611, p. 37-47,
2002. K.W. Gossage, T.S. Tkaczyk, J.J.
Rodriquez, J.K. Barton, "Texture analysis for tissue classification of optical coherence
tomography images," proc. SPIE Vol. 4958, p. 109-117, 2003. A. Tumlinson, L. Hariri,
J.K. Barton, "Miniature endoscope for a combined OCT-LIF system," proc.
SPIE
Vol. 4956, p. 129-138, 2003. J.K. Barton, N.J. Halas, J.L West,
R.A. Drezek, "Nanoshells
as an Optical Coherence Tomography Contrast Agent," proc.
SPIE Vol 5316, p. 96-106, 2004. K.W.
Gossage, C.M. Smith, E.M. Kanter, L.P. Hariri, A.L. Stone, J.J. Rodriguez, S.K.
Williams, J.K. Barton, "Texture
analysis of speckle in optical coherence tomography images of tissue phantoms,"
proc. SPIE Vol. 5318, p. 140-150, 2004.
A.R. Tumlinson, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, L. Hariri, W. Drexler, J.K. Barton, "Endoscopic ultrahigh-resolution OCT for in vivo imaging colon disease model mice," proc. SPIE, vol. 5692, p. 307-315, 2005. L. Hariri, A. Tumlinson, N. Wade, D.
Besselsen, U. Utzinger, E. Gerner, J.K. Barton. "Ex vivo optical coherence
tomography and laser induced fluorescence spectroscopy imaging of murine
gastrointestinal tract," proc. SPIE, vol. 5692, p. 295-306, 2005. J.K. Barton, S. Stromski. "Flow measurement
using speckle in optical coherence tomography imaging," Proc. SPIE, vol. 5690, p. 245-256, 2005. W. Xu, G. Bonnema, K. Gossage, N.
Wade, J. Medford, J.K. Barton. "A low cost customized analog circuit design for optical
coherence microscopy," proc. SPIE vol. 5692, p. 283-294, 2005. E. Kanter, R. Walker, S. Marion, P.
Hoyer, J.K. Barton,
"Use of multiple imaging modalities to detect ovarian cancer," proc. SPIE vol. 5686, p. 596-605, 2005. L.P. Hariri, Z. Qiu, A.R. Tumlinson,
D.G. Besselsen, E.W. Gerner, N. Ignatenko, B. Považay, B. Hermann, H.
Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J K. Barton, "Serial endoscopy in azoxymethane
treated mice using ultra-high-resolution optical coherence tomography" proc.
SPIE vol. 6432,
643208 2007. L.J. Arauz, Y. Luo, J.E. Castillo,
R.K. Kostuk, and J.K. Barton, "10-channel fiber array fabrication technique for parallel
optical coherence tomography system," proc. SPIE vol. 6429, 64292H 2007. A.R. Tumlinson, B. Hofer, B.
Považay, A. Winkler, W. Drexler, and J.K. Barton, "Inherent media dispersion
compensation by FD-OCT," proc. SPIE vol. 6429, 64291C 2007. J.K. Barton, S. Tang, R. Lim, B.J.
Tromberg, "Simultaneous Optical Coherence and Multiphoton Microscopy of
Skin-Equivalent Tissue Models," proc. SPIE vol. 6627, in press 2007. Other conference proceedings J.K. Barton, D. Smithies, M.J.C. van
Gemert, J.S. Nelson, A.J. Welch, "Monte Carlo modeling of a true port wine
stain anatomy," Conference on Lasers and Electro-optics, Baltimore, MD,
May 18-23, 1997. J.A. Izatt, M.D. Kulkarni, J.K.
Barton, A.J. Welch, "In vivo Doppler flow imaging of picoliter blood
volumes using optical coherence tomography," Conference on Lasers and
Electro-optics, Baltimore, MD, May 18-23, 1997. M.D. Kulkarni, J.A. Izatt, K.
Kobayashi, S. Yazdanfar, R.C.K. Wong, M.V. Sivak, J.K. Barton, A.J. Welch,
"Optical coherence tomography: a novel tool for micron-resolution
biomedical diagnostics," 19th Annual International Congress of
the IEEE Engineering in Medicine and Biology Society, 883-886, 1997. J.A. Izatt, M.D. Kulkarni, S.
Yazdanfar, R.C.K. Wong, J.K. Barton, A.J. Welch, "In vivo color Doppler
optical coherence tomography," OSA Annual Meeting, October 12-17, 1997. J.K. Barton, J.B. Hoying, C.J.
Sullivan, "Use of Microbubbles as an Optical Coherence Tomography Contrast
Agent," Contrast Media Research 1999 , Woodstock, VT, 9/12-17, 1999
(published in Academic Radiology 9(S1): S52-S55, 2001). J.K. Barton, G. Frangineas, H.
Pummer, J.F. Black, "Two-Color Laser Photocoagulation of Cutaneous Blood
Vessels," World Congress on Medical Physics and Biomedical Engineering,
Chicago, IL, July 23-28, 2000. Baldwin A L, Alberding J, Barton J K
and Wiley E B, "Use of optical coherence tomography to measure mechanical and
transport properties of pulsing arterial walls," Proc. 2001 Bioengineering
Conference, ASME BED-Vol. 50:677-678. T. Tkaczyk, J.K. Barton "Analysis of
optical system influences on imaging results in optical coherence tomography,"
SPIE Opto-SW, Tucson, AZ, Sept. 17-18 2001. J.K. Barton, J.F. Black,
"Time-domain optical properties of laser irradiated blood," SPIE Opto-SW,
Tucson, AZ, Sept. 17-18 2001. Lin, A., Barton, J., Halas, N., and Drezek,
R. "Nanoengineered Contrast
Agents for Biophotonics" Advances in Optics for Biotechnology, Medicine,
and Surgery. Banff, Canada. August 2003. J.K. Barton, S. Priya,
N. Wade, J.F. Black, "Dynamic optical properties of blood irradiated at 1064
nm," Annual meeting of the ASLMS, Anaheim, CA, April 2003. J.K. Barton, L. Hariri,
A. Tumlinson, "Combined optical coherence tomography and fluorescence
spectroscopy for characterization of tissues," IEEE LEOS Ann Mtg Proc. Vol. 1,
p. 458-459, 2003. J. K. Barton, S. Priya,
N. Wade, J. F. Black, "Dynamic optical properties of blood irradiated at 1064
nm," Joint International Laser Meeting, Edinburgh, Scotland, Sept 21-23 2003. G.T. Bonnema. S.K.
Williams, J.K. Barton, "Imaging vascular implant development with optical
coherence tomography," IEEE LEOS Ann Mtg Proc. Vol. 2, p. 763-764, 2004. R. K. Kostuk, M.
Scepanovic, and J. E. Castillo, ``Low coherence interferometer for accurate
fiber length measurement and fiber array device fabrication," 88th
OSA Annual Meeting, p. 95, Rochester, N. Y., 10-14 October, 2004. K. O'Halloran, Bonnema
G, Barton J, Williams SK. "Stent
Evaluation in a Blood Vessel Mimic." Surfaces in Biomaterials: BioInterface;
October 2005. Y. Luo, J. E. Castillo,
L. J. Arauz, J. K. Barton, and R. K. Kostuk, ``Modeling and experimental
measurement of scattering effects in a high parallel fiber imaging system," 89th
OSA Annual Meeting, p. 100, Tucson, AZ., 16-20 October, 2005. J. E. Castillo, Y. Luo,
L. J. Arauz, M. Scepanovic, J. K. Barton, and R. K. Kostuk, ``Ten channel
interferometer for endoscopic parallel optical coherence tomography," 89th
OSA Annual Meeting, p. 94, Tucson, AZ., 16-20 October, 2005. Y. Luo, L. J. Arauz, J.
E. Castillo, J. K. Barton, and R. K. Kostuk, ``Coherent proximity sensor with
high density fiber array," 90th OSA Annual Meeting, paper FThN1,
Rochester, N.Y., 8-12 October, 2006. V. Korde, Chetankumar
Krishnamurthy,James Ranger-Moore, David S. Alberts, Jennifer K. Barton,
"Optical Coherence Tomography as an Aid in Chemoprevention of Skin Cancer,
Lasers in Surgery and Medicine, 38(S18) p. 14, 2006. G.T. Bonnema, Cardinal
KO, Williams SK, Barton JK.
"Imaging Blood Vessel Mimics with Optical Coherence Tomography" American
Society for Laser Medicine and Surgery Annual Meeting; April 2006. K.O. Cardinal, Bonnema
GT, Barton JK, Williams SK.
"Effect of Flow on Tissue Responses to Intravascular Stents." Biomedical
Engineering Society: Unlimited Horizons; October 2006. L.J. Arauz, Y. Luo, J. Castillo, R.
Kostuk, J. Barton, "10-Channel fiber array fabrication technique for Parallel
Optical Coherence Tomography System," Photonics West BIOS 2007 Conference,
[6429-88], 20-25 January 2007, San Jose, CA. Patents 6,275,726
E.K. Chan, J.K. Barton, A.J. Welch, "Methods of enhanced light
transmission through turbid biological media," August 14, 2001 6,766,187 J.F. Black and J.K. Barton, "Method
for detecting coagulation in laser treatment of blood vessels", July 20, 2004 6,942,663
G. Vargas, J.K. Barton, E.K. Chan, T.E. Milner, A.J. Welch, "Laser
treatment of cutaneous vascular lesions," September 13, 2005 PCT/AT2006/000277 A. Tumlinson, W. Drexler, J.K.
Barton, "Optical Coherence Tomography Endoscope Utilizing a Distally Integrated
Interferometer" Research
Projects Ongoing or Recently Completed: "Molecular Targeted Imaging in Colon
Cancer" Principle Investigator: Joseph Backer,
SibTec, Inc. (Barton subcontract PI) Type: SBIR Phase I 10/01/07-03/31/08 Agency: National Institutes of
Health/ NCI R43 CA132528 Total Direct Costs: $150,000 Effort:
10% (for six months) This grant funds development of a
fluorescence contrast agent targeted to the VEGF receptor. The subcontract is
to image this agent in a mouse model using endoscopic OCT/LIF "Novel Superluminescent LEDs and Ultrahigh-resolution OCT for
medical imaging applications" (Active) Dual PI: Jennifer Barton, together
with Yong-Hang Zhang, Arizona State University Type: Research Grant 4/1/07-3/31/09 Agency: ASU-UA Collaborative on
Biomedical Research Total Direct Costs: $325,955 Effort: 5% A new class of SLED light sources
will be developed for optical coherence tomography applications, with broad
bandwidth and high power. They will be tested in a broadband OCT system with
various tissue samples. "Advanced Intravital Microscope"
(Active) Co-PI: Jennifer Barton (PI: Urs
Utzinger) Type: Shared Instrumentation Grant 04/01/07-03/31/08 Agency: National Institutes of
Health/NCRR S10 RR23737 Total Direct Costs: $457,779 This grant will support the purchase
of components to create an advanced intravital microscope, with multiphoton
imaging capabilities and the ability to measure tissue cultures and small
animals. "Advanced Intravital Microscope"
(SFA supplement) (Active) Dual PI: Jennifer Barton and Urs
Utzinger Type: Bridge Fund Grant 05/07/07-05/06/08 Agency: Science Foundation Arizona Total Direct Costs: $45,752 This grant supplements the NIH award
to build an advanced intravital microscope. "Optical Imaging of Ovarian
Carcinogenesis in a Novel Rat Model" (Active) Principal Investigator: Jennifer
Barton Type: Research Grant 12/12/06-12/11/11 Agency: National Institutes of Health/ NCI R01 CA119200 Total Direct Costs: $875,000 Effort: 15% A novel post-menopausal rat model of
ovarian cancer will be developed under this grant and imaged with optical
coherence tomography, optical coherence microscopy, and laser-induced
fluorescence. Technology development will include miniature OCT and OCM probes. "Optical Holographic
Spatial-Spectral Imaging" (Active) Principal Investigator: Raymond
Kostuk (Barton Co-investigator) Type: Research Grant 08/25/06-07/31/08 Agency: National Institutes of Health/
NCI R21 CA118167 Total Direct Costs: $154,400
Effort 7% This grant funds development of an
imaging system capable of simultaneously obtaining three spatial and one
spectral dimensions. "Dual-modality system for imaging colon cancer in mice" (Active) Principal Investigator: Jennifer Barton Type: Research Grant 07/01/04-06/30/09 Agency: National Institutes of Health/NCI R01 CA109835 Total Direct Costs $1,126,022 Effort 20% This grant funds development of a dual modality imaging
system (optical coherence tomography and fluorescence spectroscopy) and the
application of this system to minimally invasive imaging of mouse colon cancer
models. "Chemoprevention of Skin Cancer" (Active) Principal Investigator: David
Alberts (Barton investigator) Type: Program Project Grant 07/01/04-06/30/09 Agency: National Institutes of
Health/NCI P01 CA27502 Total Direct Costs: $14,403,950 Effort: 2% Barton's role in the grant is to
develop optical coherence tomography as a non-invasive biomarker for skin sundamage
and chemopreventive agent efficacy. "Contrast Agents for Optical Coherence Tomography" (Past) Principal Investigator: Marek Romanowski (Barton
Co-investigator) Type: Research Grant 07/01/04-06/30/07 Agency: Arizona Disease Control and Research Commission/
9-002 Total Direct Costs: $250,000 Effort: 5% This grant funds creation of
liposome-scaffold, gold nanoparticles for OCT imaging contrast. "Imaging the Vascular Response to Implants" (Past) Principal Investigator: Jennifer Barton Type: Independent Scientist Award 07/01/02-06/30/07 Agency: National Institutes of Health/NIBIB K02 EB000163 Total direct costs: $448,250 Effort 75% This independent scientist award provides salary support and
relief from some teaching/service activities, so that more time can be spent on
research. "A three
dimensional in vivo system for measuring gene expression" (Past) Principal Investigator: June
Medford, Colorado State Univeristy Agency: National Science Foundation
MCB-0236683 Type: Research Grant, 06/01/03-05/31/05 Total direct costs for UA
subcontract: $4000 Effort 4% Barton is co-PI on this grant to build an optical coherence
microscope and use it for imaging gene expression in Arabidopsis. "Parallel Optical Coherence Tomography for Endoscopic
Imaging" (Past) Principal Investigator: Jennifer Barton Type: Research Grant 10/01/02-03/31/07 Agency: National Institutes of Health/NIBIB R01 EB01032 Total Direct Costs $690,642 Effort 25% This project fund development of a novel, parallel-imaging
OCT system, using arrays of superluminescent diodes, detectors, and CMOS
processing channels. Feasibility will be tested by imaging the bladders of
rabbits and humans. "Southwest Small Animal Imaging
Resource" (Past) Co-Principal
Investigator: Jennifer K. Barton Agency:
National Institutes of Health, CA83148 Type: Small
Animal Imaging Resource, 10/01/99 - 09/30/04 Total
direct costs: $ 4,215,093
Effort: 25% The PI on
this grant is Robert J. Gillies. Dr. Barton's involvement is to build an OCT
system specifically for small animal imaging. "Optical
Imaging and Spectroscopy of Mouse GI tissue" (Past) Principal Investigator: Jennifer Barton Type: Pilot Project in Cancer Research 07/01/02-03/31/04 Agency: National Institutes of Health/NCI Total direct costs: $56,000 Effort: 10 % This grant was awarded through the University of Arizona
Cancer Center SPORE in GI Cancers (Eugene Gerner PI), and provides support to
perform initial studies of OCT and spectroscopy of mouse gastrointestinal
tissues. "Imaging
the Healing Response of Glaucoma Implants" (Past) Principal
Investigator: Jennifer K. Barton Agency:
Whitaker Foundation Type:
Research Grant, 12/01/00-11/30/03 ncx 5/31/04 Total
direct costs: $176,220 Effort: 20% This grant
is for development of optical probes and signal processing techniques to
evaluate the healing response of three types of implants to treat end-stage
glaucoma. "Vascular
Imaging with Optical Low-Coherence Techniques" (Past) Principal
Investigator: Jennifer K. Barton Agency:
National Science Foundation Type:
Research Grant, 9/01/99 – 8/31/02 ncx 8/31/03 Total
direct costs: $185,923
Effort: 17% This grant
is for development of hardware and software to perform imaging and
characterization of the vascular
system with OCT and other low coherence techniques. Classes
Taught: BME 417/517 Measurement
and Data Analysis in Biomedical Engineering ECE 340 Engineering
Systems Analysis ECE 4/529 Digital
Signal Processing OPTI/BME 630 Biomedical
Imaging and Biophotonics Students
Graduated: 2000 Kristi Hansen, M.S. Biomedical Engineering (Engineer, Sebra,
Tucson, AZ) 2001 Xianfeng Li, M.S. Electrical Engineering (Software Engineer,
Kronos, Inc., Beaverton, OR) 2003 Alexandre Tumlinson, M.S. Optical Sciences (Ph.D. student in
BME, U. Arizona) 2003 Steven Stromski, M.S. Optical Sciences (Engineer,
Envisioneering, Inc., VA) 2003 Ajay Jain, M.S. Electrical Engineering (Conexant Systems,
Hyderabad, India) 2004 Kirk Gossage, Ph.D. Biomedical Engineering, "Optical
Coherence Tomography and Texture Analysis: Non-Invasive Monitoring of Tissue
Response to Glaucoma Implant" (Staff Scientist, Cambridge Research &
Instrumentation, Inc., Woburn, MA) 2005 Elizabeth Kanter, M.S. Biomedical Engineering (Ph.D.
student, Vanderbilt U.) 2005 James McNally, M.S. Optical Sciences (Engineer, Boston
Scientific, Natick, MA) 2006 Wei Xu, Ph.D. Systems and Industrial Engineering, "Analog
Signal Processing for Optical Coherence Imaging Systems" (Engineer, Texas
Instruments Inc., Tucson, AZ) 2007 Lida
Hariri, Ph.D. Biomedical Engineering, "Optical Coherence Tomography and Laser
Induced Fluorescence in Mouse Models of Colorectal Cancer" (Continuing as
Medical Student in MD/PhD program, The University of Arizona) 2007 Alexandre
Tumlinson, Ph.D. Biomedical Engineering, "Ultrahigh-resolution endoscopic
optical coherence tomography for in vivo mouse colonoscopy" (Post-doctoral
Associate, Cardiff University) Student
Awards: 2001 Kirk Gossage, Arizona Graduate Imaging Fellowship 2001 Jonathan Alberding, NIH Predoctoral Fellowship for Students
with Disabilities (co-sponsor) 2003 Alexandre Tumlinson, Arizona Graduate Imaging Fellowship 2004 Alexandre Tumlinson, Fulbright Comprehensive Grant (to
University of Vienna) 2004 Garret Bonnema, Christopher Karl Schultz Memorial Scholarship 2005 James McNally, Arizona Graduate Imaging Fellowship 2005 Ross Walker, Outstanding Electrical Engineering Senior of
the Class 2005 Ross Walker, International Engineering Consortium Award 2006, 2007 Amy Winkler, Achievement Rewards for College Scientists
(ARCS) Fellowship 2006 Lida Hariri, P.E.O. Scholar Award 2006 Lida Hariri, Arizona Graduate Imaging Fellowship 2007 Vrushali Korde, SPIE Scholarship Award in Optical Science
and Engineering 2007 Varun Bhartia, Outstanding College of Engineering Senior |
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