Jennifer Kehlet Barton, Ph.D.

Education:

1988 B.S., Electrical Engineering, The University of Texas at Austin

1993 M.S., Electrical Engineering, The University of California, Irvine

1998 Ph.D., Biomedical Engineering, The University of Texas at Austin

Positions:

1988-1994 McDonnell Douglas Aerospace (now Boeing Corp.), Huntington Beach, CA. Engineer/Scientist Specialist, International Space Station

1994-1998 The University of Texas, Austin, TX. Research Assistant, Biomedical Engineering Program

1998-pres. The University of Arizona, Tucson, AZ. Assistant Professor (1998-2003), Associate Professor (2003-pres.) Biomedical Engineering (primary appointment), Electrical and Computer Engineering Department, College of Optical Sciences, Arizona Cancer Center, Bio5 Institute

2006 Visiting Scientist, Beckman Laser Institute, The University of California, Irvine

2007-pres. Chair, Biomedical Engineering Graduate Interdisciplinary Program, The University of Arizona

2007-pres. Director, Division of Biomedical Engineering, The University of Arizona

Professional Activities:

2003-2007 National Institutes of Health Biomedical Imaging Technology (BMIT, formerly DMG) Study Section Charter Member (3 review sessions per year)

Various: Proposal reviewer for: National Science Foundation, National Institutes of Health ad hoc and site visit committees, California Breast Cancer Research Program, California Tobacco-Related Disease Research Program, Philip Morris External Research Program, The University of Arizona Small Grants Program, Center for Integration of Medicine and Innovative Technology, Technology Foundation STW (Dutch Foundation), Connecticut Innovations, Science and Technology Center Ukraine

Various: Journal Reviewer for: Annals of Biomedical Engineering, Applied Optics, Dermatological Surgery, Expert Reviews in Dermatology, IEEE Transactions on Biomedical Engineering, IEEE Transactions on Education, IEEE Transactions on Medical Imaging, Journal of Biomedical Optics, Journal of Lightwave Technology, Journal of the Optical Society of America, Lasers in Surgery and Medicine, Medical Physics, Microcirculation, Nature Photonics, Optics Express, Optics and Lasers in Engineering, Optics Letters, Physics in Medicine and Biology, Technology in Cancer Research and Treatment

Societies:

American Society for Laser Medicine and Surgery: Fellow; 2004-2007 Board of Directors; 2004-pres. Research and Development Committee; 2005-2006 Ethics Committee; 2002,3,4,5,6,7 Session chair Annual meeting

Biomedical Engineering Society: Member; 2000-pres. Faculty Advisor UA student chapter; 2003 Session chair for Annual Meeting

Institute of Electrical and Electronic Engineers: Member; 2004 Committee IEEE LEOS annual meeting

Optical Society of America: Member; 2003 Optics in Biology and Medicine vice-chair; 2003, 2005 Session chair annual meeting

SPIE: Fellow; 2001 Co-chair, SPIE Opto-Southwest, Conference on Optical Imaging in Medicine; 2003,4,5,6,7,8 Session chair and program committee, Photonics West; 2005-pres. Co-chair International Biomedical Optics Society; 2005,7 Session chair and program committee European Conferences on Biomedical Optics; 2006 Women in Optics Calendar of Days; 2006 Featured in “Your Society” Member Guide; 2006 Essay in SPIE “50 Years” publication

Awards:

1996,1997 NASA/Texas Space Grant Fellowship

1996,1997 A.D. Hutchinson/University of Texas Endowment Fellowship

1997 SPIE D.J. Lovell Scholarship

1998 Research Paper Award, 18th Ann. Mtg, ASLMS

• Award for Excellence at the Student Interface, College of Engineering and Mines

Publications:

Peer Reviewed Articles:

Barton JK , Milner TE, Pfefer TJ, Nelson JS, Welch AJ: Optical low coherence reflectometry to enhance Monte Carlo modeling of skin. Journal of Biomedical Optics, 2(2):226-234, 1997.

Pfefer TJ, Barton JK, Chan EK, Ducros MG, Sorg BS, Welch AJ: A three dimensional modular adaptable grid numerical model for light propagation during laser irradiation of skin tissue. Journal of Selected Topics in Quantum Electronics, 2(4):934-942, 1997.

Wright CHG, Barton JK, Protsenko DE, Rylander HG, Welch AJ: Anomalous reflectance of laser-induced retinal lesions. Journal of Selected Topics in Quantum Electronics, 2(4):1035-1040, 1997.

Izatt JA, Kulkarni MD, Yazdanfar S, Barton JK, Welch AJ: In vivo bidirectional Doppler flow imaging of picoliter blood volumes using optical coherence tomography. Optics Letters, 22(18):1439-1441, 1997.

Choi B, Barton JK, Chan EK, Welch AJ: Imaging of the irradiation of skin with a clinical CO 2 laser system: Implications for laser skin resurfacing: Lasers in Surgery and Medicine, 23:185-193, 1998.

Barton JK , Pfefer TJ, Welch AJ, Smithies DJ, Nelson JS, van Gemert MJC: Optical Monte Carlo modeling of a true port wine stain anatomy. Optics Express 2, 391, 1998.

Barton JK , Izatt JA, Welch AJ: Investigating pulsed dye laser-blood vessel interaction with color Doppler optical coherence tomography. Optics Express 2:251-256, 1998.

Barton JK , Izatt JA, Kulkarni MD, Yazdanfar S, and Welch AJ: Three-dimensional reconstruction of blood vessels from in vivo color Doppler optical coherence tomography images. Dermatology, 198:355-361, 1999.

Barton JK , Hammer DX, Pfefer TJ, Lund TJ, Stuck BE, Welch AJ: Simultaneous irradiation and imaging of cutaneous blood vessels. Lasers in Surgery and Medicine, 24:236-243, 1999.

Choi B, Chan EK, Barton JK, Thomsen SL, Welch AJ: Thermographic and histological evaluation of laser skin resurfacing scans. IEEE Journal of Selected Topics in Quantum Electronics, 5:1116-1126, 1999.

Vargas G, Chan EK, Barton JK, Rylander HG, Welch AJ: Use of an agent to reduce scattering in skin. Lasers in Surgery and Medicine, 24:133-141 1999.

Pfefer TJ, Barton JK, Smithies DJ, Milner TE, Nelson JS, van Gemert MJC, Welch AJ: Modeling laser treatment of port wine stains with a computer-reconstructed biopsy. Lasers in Surgery and Medicine, 24:151-166, 1999.

Barton JK , Vargas G, Pfefer TJ, Welch AJ: Laser fluence for permanent damage of cutaneous blood vessels. Photochemistry and Photobiology, 70:916-920, 1999.

Barton JK , Rollins A, Yazdanfar S, Pfefer TJ, Westphal V, Izatt JA: Photothermal coagulation of blood vessels: a comparison of high-speed optical coherence tomography and numerical modeling. Physics in Medicine and Biology, 46:1665-1678, 2001.

Barton JK , Frangineas G, Pummer H, Black JF: Cooperative phenomena in two-pulse, two-color laser photocoagulation of cutaneous blood vessels. Photochemistry and Photobiology, Jun;73(6):642-50, 2001.

Barton JK , Popok D, Black JF: Thermal analysis of blood undergoing laser photocoagulation. IEEE Journal of Selected Topics in Quantum Electronics, 7:936-943, 2001.

Wong RC, Yazdanfar S, Izatt JA, Kulkarni M, Barton JK, Welch AJ, Willis J, Sivak MV: Visualization of subsurface blood vessels by color Doppler-optical coherence tomography in rats: before and after hemostatic therapy. Gastrointestinal Endoscopy, 55(1):88-95, 2002.

Hansen KA, Weiss JA, Barton JK: Recruitment of tendon crimp with applied tensile strain. Journal of Biomechanical Engineering, 124:72-77, 2002.

Rollins AM, Yazdanfar S, Barton JK, and Izatt JA: Real-time in vivo color Doppler optical coherence tomography. Journal of Biomedical Optics, 7:123-129, 2002.

Gossage K, Tkaczyk T, Rodriguez J, Barton JK: Texture Analysis of Optical Coherence Tomography Images: Feasibility for Tissue Classification,” Journal of Biomedical Optics 8:570-575, 2003.

Loeb G, Barton JK: Optical Coherence Tomography for Morphological Imaging of Fruits. Transactions of the American Society of Agricultural Engineering, 46:1751-1757, 2003.

Barton JK , Gossage KW, Xu W, Ranger-Moore J, Saboda K, Brooks CA, Duckett LD, Salache SJ, Warneke JA, Alberts DS: Investigating sundamaged skin and actinic keratosis with optical coherence tomography: a pilot study. Technology in Cancer Research and Treatment, 2:525-535, 2003.

Tumlinson AR, Hariri LP, Utzinger U, Barton JK: A miniature endoscope for simultaneous OCT-LIF measurement. Applied Optics, 43:113-121, 2004.

Barton JK , Guzman F, Tumlinson AR: Dual modality instrument for simultaneous optical coherence tomography imaging and fluorescence spectroscopy. Journal of Biomedical Optics, 9:618-623, 2004.

Alberding J, Barton JK, Wiley EB, Baldwin AL: Onset of pulsatile pressure causes transiently increased filtration through artery wall, American Journal of Physiology, Heart Circ. Physiol., 286:H1827-35, 2004.

Loo C, Lin A, Hirsch L, Lee M, Barton JK, Halas N, West J, Drezek R: Nanoshell-enabled photonics-based imaging and therapy of cancer, Technology in Cancer Research and Treatment, 3:33-40 2004.

Scepanovic M, Castillo JE, Barton JK, Mathine D, Kostuk RK, Sato A: Design and processing of high-density single-mode fiber arrays for imaging and parallel interferometer applications, Appl. Opt. 43: 4150-4156, 2004.

Brewer M, Utzinger U, Barton JK, Hoying JB, Kirkpatrick ND, Brands WR, Davis JR, Hunt K, Stevens SJ, Gmitro AF, Imaging of the Ovary, Technology in Cancer Research and Treatment, 3: 617-628, 2004.

Kariya R, Mathine DL, Barton JK, Analog CMOS Circuit Design and Characterization for Optical Coherence Tomography Signal Processing, IEEE Transactions on Biomedical Engineering, 51:2160-3, 2004.

Black JF and Barton JK, “Chemical and Structural Changes in Blood Undergoing Laser Photocoagulation,” Photochemistry and Photobiology, 80:89-97, 2004.

Black JF, Wade N, Barton JK, “Mechanistic comparison of blood undergoing laser photocoagulation at 532 and 1,064 nm,” Lasers Surg. Med. 36:155-165, 2005.

Barton JK , Stromski S, "Flow measurement without phase information in optical coherence tomography images," Optics Express, 13:5234-5239, 2005.

Alberding JP, Baldwin AL, Barton JK, Wiley E, “Effects of pulsation frequency and endothelial integrity on enhanced arterial transmural filtration produced by pulsatile pressure,” Am J Physiol Heart Circ Physiol. 289(2):H931-7 2005.

Gossage KW, Smith CM, Kanter EM, Hariri LP, Stone AL, Rodriguez JJ, Williams SK, Barton JK, “Texture analysis of speckle in optical coherence tomography images of tissue phantoms", Physics in Medicine and Biology, 51:1563-1575, 2006.

Hariri LP, Tumlinson AR, Wade NH, Besselsen D, Utzinger U, Gerner E, Barton JK , “Endoscopic optical coherence tomography and laser induced fluorescence spectroscopy in a murine colon cancer model,” Lasers in Surgery and Medicine, 38:305-313, 2006.

Xu W, Bonnema GT, Gossage KW, Wade NH, Medford J, Barton JK , “Customized analog circuit design for fiber based optical coherence microscopy,” Review of Scientific Instruments 77: 016104, 2006.

McNally J, Kirkpatrick N, Hariri LP, Tumlinson AR, Besselsen D, Gerner E, Urs Utzinger U, Barton J., “Task Based Imaging of Colon Cancer in a Mouse Model (Apc Min/+ ),” Applied Optics, 45: 3049-3062, 2006 .

Kanter EM, Walker RM, Marion SL, Brewer M, Hoyer PB, Barton JK, “ Dual modality imaging of a novel rat model of ovarian carcinogenesis,” Journal of Biomedical Optics, Vol. 11, 041123, 2006.

Agrawal A, Huang S, Wei A, Lin H, Lee M, Barton JK, Drezek R, Pfefer J, “Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells, ” Journal of Biomedical Optics, Vol. 11, 041121, 2006 .

Tumlinson AR, Barton JK, Povazay B, Sattman H, Unterhuber A, Leitgeb RA, Drexler W, “Endoscope-tip interferometer for ultrahigh resolution frequency domain optical coherence tomography in mouse colon,” Optics Express, 14: 1878-1887, 2006.

Xu W, Mathine DL, Barton JK, “High-gain differential CMOS transimpedance amplifier with on-chip buried double junction photodiode,” Electronics Letters 42(14):803-5, 2006.

Tumlinson AR, Povazay B, Hariri LP, McNally J, Unterhuber A, Hermann B, Sattmann H, Drexler W, Barton JK, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” Journal of Biomedical Optics, 11:064003, 2006.

Cardinal KO, Bonnema GT, Hofer H, Barton JK, Williams SK, "Tissue Engineered Vascular Grafts as In Vitro Blood Vessel Mimics to Evaluate Endothelialization of Intravascular Devices" Tissue Engineering, 12:3431-8, 2006.

Luo Y , Castillo J, Arauz L, Barton JK, Kostuk RK , "Coupling and crosstalk effects in high density fiber imaging," Applied Optics 26:253-261, 2007.

Hariri LP, Tumlinson AR, Wade NH, Besselsen DG, Utzinger U, Gerner EW, Barton JK, “Ex Vivo Optical Coherence Tomography and Laser-induced Fluorescence Spectroscopy Imaging of Murine Gastrointestinal Tract,” Comparative Medicine, 57 02 04, 2007.

Bonnema GT, Cardinal KO, McNally JB, Williams SK, Barton JK, “Assessment of Blood Vessel Mimics with Optical Coherence Tomography,” Journal of Biomedical Optics, 12:024018, 2007.

Troutman T, Barton JK, Romanowski M, “Optical Coherence Tomography with Plasmon Resonant Nanorods of Gold,” Optics Letters, 32:1438-1440, 2007.

Xu W, Mathine DL, Barton JK, “Analog CMOS design for optical coherence tomography signal detection and processing,” IEEE Transactions on Biomedical Engineering, accepted.

Hariri LP, Qiu L, Tumlinson AR, Besselsen DG, Gerner EG, Ignatenko N, Povazay B, Hermann B, Sattmann H, McNally J, Unterhuber, Drexler W, Barton JK, “Serial endoscopy in azoxymethane treated mice using ultrahigh resolution optical coherence tomography,” Cancer Biology and Therapy, accepted.

Luo Y, Arauz L, Castillo J, Barton JK, Kostuk R, “Parallel Optical Coherence Tomography System” Applied Optics, accepted.

Korde V, Bonnema G, Xu W, Krishnamurthy C, Ranger-Moore J, Saboda K, Slayton L, Salasche S, Warneke J, Alberts D, and Barton J, “Using Optical Coherence Tomography to Evaluate Skin Sun Damage and Precancer”, Lasers in Surgery and Medicine, 39:687-695, 2007.

Tumlinson AR, Hofer B, Winkler A, Povazay B, Drexler W, Barton JK, Inherent homogenous media dispersion compensation in frequency domain optical coherence tomography by accurate “k-sampling”, in press.

Book Chapters:

J.K. Barton , A. Tumlinson, U. Utzinger, “Combined Endoscopic Optical Coherence Tomography and Laser Induced Fluorescence,” in Handbook of Optical Coherence Tomography, W. Drexler and J. Fujimoto, eds. to be published March 2008.

J.K Barton , “Dynamic Optical Properties,” in Optical-Thermal Response to Laser-Irradiated Tissues, A.J. Welch and M.J.C. van Gemert, eds. to be published in 2008.

Periodical and other publications:

J.A. Izatt, M.D. Kulkarni, K. Kobayashi, M.V. Sivak, J.K. Barton, and A.J. Welch, "Optical Coherence Tomography for Biodiagnostics," Optics and Photonics News 8:41-47, 1997.

J.K. Barton , "Optical Coherence Tomography," McGraw-Hill 2000 Yearbook of Science and Technology, McGraw-Hill, New York, NY, 2000.

J.F. Black and J.K. Barton “Two-photon laser techniques for diagnostic and therapeutic medicine,” DOPS-NYT Journal of the Danish Optical Society, 4:29-33 2001.

Full-length Manuscript Conference Proceedings:

E.K. Chan, B. Amini, J.K. Barton, A.J. Welch, S.L. Thomsen, R.C. Stoneman, L. Esterowitz. “Wavelength dependency of soft tissue coagulation with a tunable cw laser,” proc. SPIE, 2581, p. 102-113, 1996.

J.K. Barton , J.A. Izatt, M.D. Kulkarni, A.J. Welch, "Three-dimensional reconstruction of rat dermal blood vessels in vivo," proc. SPIE, v. 2970, p. 266-275, 1997.

A.J. Welch, E.K. Chan, J.K. Barton, B. Choi, S. L. Thomsen. “Infrared imaging of CO2 laser resurfacing,” proc. SPIE, 2970, p. 305-311, 1997.

T.J. Pfefer, J.K. Barton, E.K. Chan, M.G. Ducros, B.S. Sorg, T.E. Milner, J.S. Nelson, A.J. Welch. “ Adaptable three-dimensional Monte Carlo modeling of imaged blood vessels in skin ,” proc. SPIE, 2975 p. 2-13, 1997.

J.K. Barton J.A. Izatt, A.J. Welch, "Investigating laser-blood vessel interaction with color Doppler optical coherence tomography." proc. SPIE, 3251 p. 102-113, 1998.

S. Yazdanfar, M.D. Kulkarni, R.C.K. Wong, M.V. Sivak, J. Willis, J.K. Barton, A.J. Welch, J.A. Izatt, "Diagnostic blood flow monitoring during therapeutic interceptions using color Doppler optical coherence tomography," proc. SPIE, 3251 p. 126-132, 1998.

B. Choi, J.K. Barton, E.K. Chan, S.L. Thomsen, A.J. Welch, "Infrared imaging of CO2 laser ablation: Implications for laser skin resurfacing," proc. SPIE, 3245 p. 344-355, 1998.

T.J. Pfefer, J.K. Barton, D. Smithies, T.E. Milner, M.J.C. van Gemert, J.S. Nelson, A.J. Welch, "Laser Treatment of Port Wine Stains: Three-Dimensional Simulation Using Biopsy-Defined Geometry in an Optical-Thermal Model," proc. SPIE, 3245 p. 322-333, 1998.

G. Vargas, J.K. Barton, B. Choi, J.A. Izatt, A.J. Welch, "Assessing vessel damage with color Doppler optical coherence tomography," proc. SPIE, 3598, p.185-194, 1999.

J.K. Barton , D.B. Dal Ponte, S/K. Williams, B.K. Ford, M.R. Descour, “Imaging vascular implants with optical coherence tomography,” proc. SPIE Vol. 3915, p. 229-236, 2000.

K.A. Hansen, J.K. Barton, J.A. Weiss, Optical coherence tomography imaging of collagenous tissue microstructure proc. SPIE Vol. 3914, p. 581-587, 2000.

G. Vargas, J.K. Barton, A.J. Welch, “Selective photocoagulation of cutaneous blood vessels with evaluation of vessel damage by color Doppler optical coherence tomography,” proc. SPIE 3907:136-142, 2000.

J.K. Barton , A.M. Rollins, S. Yazdanfar, T.J. Pfefer, V. Westphal, J.A. Izatt, “Optical-thermal model verification by high-speed optical coherence tomography,” proc. SPIE Vol. 4251, p. 174-182, 2001.

F. Guzman, J.K. Barton, “Dual OCT/spectroscopy system for identification of vascular pathology,” proc. SPIE Vol. 4244, p. 413-418, 2001.

J.F. Black, J.K. Barton, “Cooperative phenomena in two-pulse two-color laser photocoagulation of cutaneous blood vessels, proc. SPIE vol. 4244, p. 13-24, 2001.

J.K. Barton , S.J. Loui, J.F. Black, “Optical and magnetic resonance changes in photothermally coagulating blood,” proc. SPIE Vol. 4609:10-19, 2002.

T.S. Tkaczyk, K.W. Gossage, J.K. Barton, “Speckle image properties in optical coherence tomography,” proc. SPIE Vol. 4619, p. 59-70, 2002.

F. Guzman, J.K. Barton, “Catheter-based instrument for simultaneous OCT imaging and fluorescence spectroscopy,” proc. SPIE Vol. 4609, p. 430-437, 2002.

K.W. Gossage, T.S. Tkaczyk, J.K. Barton, “Using optical coherence tomography to evaluate glaucoma implant healing response in rabbit eyes,” proc. SPIE Vol. 4611, p. 37-47, 2002.

K.W. Gossage, T.S. Tkaczyk, J.J. Rodriquez, J.K. Barton, “Texture analysis for tissue classification of optical coherence tomography images,” proc. SPIE Vol. 4958, p. 109-117, 2003.

A. Tumlinson, L. Hariri, J.K. Barton, “Miniature endoscope for a combined OCT-LIF system,” proc. SPIE Vol. 4956, p. 129-138, 2003.

J.K. Barton , N.J. Halas, J.L West, R.A. Drezek, “ Nanoshells as an Optical Coherence Tomography Contrast Agent,” proc. SPIE Vol 5316, p. 96-106, 2004.

K.W. Gossage, C.M. Smith, E.M. Kanter, L.P. Hariri, A.L. Stone, J.J. Rodriguez, S.K. Williams, J.K. Barton, “Texture analysis of speckle in optical coherence tomography images of tissue phantoms,” proc. SPIE Vol. 5318, p. 140-150, 2004.

A.R. Tumlinson, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, L. Hariri, W. Drexler, J.K. Barton, "Endoscopic ultrahigh-resolution OCT for in vivo imaging colon disease model mice," proc. SPIE, vol. 5692, p. 307-315, 2005.

L. Hariri, A. Tumlinson, N. Wade, D. Besselsen, U. Utzinger, E. Gerner, J.K. Barton. "Ex vivo optical coherence tomography and laser induced fluorescence spectroscopy imaging of murine gastrointestinal tract," proc. SPIE, vol. 5692, p. 295-306, 2005.

J.K. Barton , S. Stromski. “Flow measurement using speckle in optical coherence tomography imaging,” Proc. SPIE, vol. 5690, p. 245-256, 2005.

W. Xu, G. Bonnema, K. Gossage, N. Wade, J. Medford, J.K. Barton. “A low cost customized analog circuit design for optical coherence microscopy,” proc. SPIE vol. 5692, p. 283-294, 2005.

E. Kanter, R. Walker, S. Marion, P. Hoyer, J.K. Barton, “Use of multiple imaging modalities to detect ovarian cancer,” proc. SPIE vol. 5686, p. 596-605, 2005.

L.P. Hariri, Z. Qiu, A.R. Tumlinson, D.G. Besselsen, E.W. Gerner, N. Ignatenko, B. Považay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high-resolution optical coherence tomography” proc. SPIE vol. 6432, 643208 2007.

L.J. Arauz, Y. Luo, J.E. Castillo, R.K. Kostuk, and J.K. Barton, “10-channel fiber array fabrication technique for parallel optical coherence tomography system,” proc. SPIE vol. 6429, 64292H 2007.

A.R. Tumlinson, B. Hofer, B. Považay, A. Winkler, W. Drexler, and J.K. Barton, “Inherent media dispersion compensation by FD-OCT,” proc. SPIE vol. 6429, 64291C 2007.

J.K. Barton, S. Tang, R. Lim, B.J. Tromberg, “Simultaneous Optical Coherence and Multiphoton Microscopy of Skin-Equivalent Tissue Models,” proc. SPIE vol. 6627, in press 2007.

Other conference proceedings

J.K. Barton, D. Smithies, M.J.C. van Gemert, J.S. Nelson, A.J. Welch, "Monte Carlo modeling of a true port wine stain anatomy," Conference on Lasers and Electro-optics, Baltimore, MD, May 18-23, 1997.

J.A. Izatt, M.D. Kulkarni, J.K. Barton, A.J. Welch, "In vivo Doppler flow imaging of picoliter blood volumes using optical coherence tomography," Conference on Lasers and Electro-optics, Baltimore, MD, May 18-23, 1997.

M.D. Kulkarni, J.A. Izatt, K. Kobayashi, S. Yazdanfar, R.C.K. Wong, M.V. Sivak, J.K. Barton, A.J. Welch, "Optical coherence tomography: a novel tool for micron-resolution biomedical diagnostics," 19 th Annual International Congress of the IEEE Engineering in Medicine and Biology Society, 883-886, 1997.

J.A. Izatt, M.D. Kulkarni, S. Yazdanfar, R.C.K. Wong, J.K. Barton, A.J. Welch, "In vivo color Doppler optical coherence tomography," OSA Annual Meeting, October 12-17, 1997.

J.K. Barton, J.B. Hoying, C.J. Sullivan, "Use of Microbubbles as an Optical Coherence Tomography Contrast Agent," Contrast Media Research 1999 , Woodstock, VT, 9/12-17, 1999 (published in Academic Radiology 9(S1): S52-S55, 2001).

J.K. Barton, G. Frangineas, H. Pummer, J.F. Black, “Two-Color Laser Photocoagulation of Cutaneous Blood Vessels,” World Congress on Medical Physics and Biomedical Engineering, Chicago, IL, July 23-28, 2000.

Baldwin A L, Alberding J, Barton J K and Wiley E B, “Use of optical coherence tomography to measure mechanical and transport properties of pulsing arterial walls," Proc. 2001 Bioengineering Conference, ASME BED-Vol. 50:677-678.

T. Tkaczyk, J.K. Barton “Analysis of optical system influences on imaging results in optical coherence tomography,” SPIE Opto-SW, Tucson, AZ, Sept. 17-18 2001.

J.K. Barton, J.F. Black, “Time-domain optical properties of laser irradiated blood,” SPIE Opto-SW, Tucson, AZ, Sept. 17-18 2001.

Lin, A., Barton, J., Halas, N., and Drezek, R. "Nanoengineered Contrast Agents for Biophotonics" Advances in Optics for Biotechnology, Medicine, and Surgery. Banff, Canada. August 2003.

J.K. Barton, S. Priya, N. Wade, J.F. Black, “Dynamic optical properties of blood irradiated at 1064 nm,” Annual meeting of the ASLMS, Anaheim, CA, April 2003.

J.K. Barton, L. Hariri, A. Tumlinson, “Combined optical coherence tomography and fluorescence spectroscopy for characterization of tissues,” IEEE LEOS Ann Mtg Proc. Vol. 1, p. 458-459, 2003.

J. K. Barton, S. Priya, N. Wade, J. F. Black, “Dynamic optical properties of blood irradiated at 1064 nm,” Joint International Laser Meeting, Edinburgh, Scotland, Sept 21-23 2003.

G.T. Bonnema. S.K. Williams, J.K. Barton, “Imaging vascular implant development with optical coherence tomography,” IEEE LEOS Ann Mtg Proc. Vol. 2, p. 763-764, 2004.

R. K. Kostuk, M. Scepanovic, and J. E. Castillo, ``Low coherence interferometer for accurate fiber length measurement and fiber array device fabrication,’’ 88 th OSA Annual Meeting, p. 95, Rochester, N. Y., 10-14 October, 2004.

K. O’Halloran, Bonnema G, Barton J, Williams SK. “Stent Evaluation in a Blood Vessel Mimic.” Surfaces in Biomaterials: BioInterface; October 2005.

Y. Luo, J. E. Castillo, L. J. Arauz, J. K. Barton, and R. K. Kostuk, ``Modeling and experimental measurement of scattering effects in a high parallel fiber imaging system,’’ 89 th OSA Annual Meeting, p. 100, Tucson, AZ., 16-20 October, 2005.

J. E. Castillo, Y. Luo, L. J. Arauz, M. Scepanovic, J. K. Barton, and R. K. Kostuk, ``Ten channel interferometer for endoscopic parallel optical coherence tomography,’’ 89 th OSA Annual Meeting, p. 94, Tucson, AZ., 16-20 October, 2005.

Y. Luo, L. J. Arauz, J. E. Castillo, J. K. Barton, and R. K. Kostuk, ``Coherent proximity sensor with high density fiber array,’’ 90 th OSA Annual Meeting, paper FThN1, Rochester, N.Y., 8-12 October, 2006.

V. Korde, Chetankumar Krishnamurthy,James Ranger-Moore, David S. Alberts, Jennifer K. Barton, "Optical Coherence Tomography as an Aid in Chemoprevention of Skin Cancer, Lasers in Surgery and Medicine, 38(S18) p. 14, 2006.

G.T. Bonnema, Cardinal KO, Williams SK, Barton JK. “Imaging Blood Vessel Mimics with Optical Coherence Tomography” American Society for Laser Medicine and Surgery Annual Meeting; April 2006.

K.O. Cardinal, Bonnema GT, Barton JK, Williams SK. “Effect of Flow on Tissue Responses to Intravascular Stents.” Biomedical Engineering Society: Unlimited Horizons; October 2006.

L.J. Arauz, Y. Luo, J. Castillo, R. Kostuk, J. Barton, “10-Channel fiber array fabrication technique for Parallel Optical Coherence Tomography System,” Photonics West BIOS 2007 Conference, [6429-88], 20-25 January 2007, San Jose, CA.

Patents

6,275,726 E.K. Chan, J.K. Barton, A.J. Welch, “Methods of enhanced light transmission through turbid biological media,” August 14, 2001

6,766,187 J.F. Black and J.K. Barton, “Method for detecting coagulation in laser treatment of blood vessels”, July 20, 2004

6,942,663 G. Vargas, J.K. Barton, E.K. Chan, T.E. Milner, A.J. Welch, “Laser treatment of cutaneous vascular lesions,” September 13, 2005

PCT/AT2006/000277 A. Tumlinson, W. Drexler, J.K. Barton, “Optical Coherence Tomography Endoscope Utilizing a Distally Integrated Interferometer”

Research Projects Ongoing or Recently Completed:

“Molecular Targeted Imaging in Colon Cancer”

Principle Investigator: Joseph Backer, SibTec, Inc. (Barton subcontract PI)

Type: SBIR Phase I 10/01/07-03/31/08

Agency: National Institutes of Health/ NCI R43 CA132528

Total Direct Costs: $150,000 Effort: 10% (for six months)

This grant funds development of a fluorescence contrast agent targeted to the VEGF receptor. The subcontract is to image this agent in a mouse model using endoscopic OCT/LIF

“Metrology Applications of OCT”

Principle Investigator: Jennifer Barton

Type: Contract 4/1/07-3/31/08

Company: CIBA Vision

Total Direct Costs: $28,960 Effort: 1%

This contract covers efforts related to developing automated metrology of contact lenses

“Novel Superluminescent LEDs and Ultrahigh-resolution OCT for medical imaging applications”

Dual PI: Jennifer Barton, together with Yong-Hang Zhang, Arizona State University

Type: Research Grant 4/1/07-3/31/09

Agency: ASU-UA Collaborative on Biomedical Research

Total Direct Costs: $325,955 Effort: 5%

A new class of SLED light sources will be developed for optical coherence tomography applications, with broad bandwidth and high power. They will be tested in a broadband OCT system with various tissue samples.

“Advanced Intravital Microscope”

Co-PI: Jennifer Barton (PI: Urs Utzinger)

Type: Shared Instrumentation Grant 04/01/07-03/31/08

Agency: National Institutes of Health/NCRR S10 RR23737

Total Direct Costs: $457,779

This grant will support the purchase of components to create an advanced intravital microscope, with multiphoton imaging capabilities and the ability to measure tissue cultures and small animals.

“Advanced Intravital Microscope” (SFA supplement)

Dual PI: Jennifer Barton and Urs Utzinger

Type: Bridge Fund Grant 05/07/07-05/06/08

Agency: Science Foundation Arizona

Total Direct Costs: $45,752

This grant supplements the NIH award to build an advanced intravital microscope.

“Optical Imaging of Ovarian Carcinogenesis in a Novel Rat Model”

Principal Investigator: Jennifer Barton

Type: Research Grant 12/12/06-12/11/11

Agency: National Institutes of Health/ NCI R01 CA119200

Total Direct Costs: $875,000 Effort: 15%

A novel post-menopausal rat model of ovarian cancer will be developed under this grant and imaged with optical coherence tomography, optical coherence microscopy, and laser-induced fluorescence. Technology development will include miniature OCT and OCM probes.

“Optical Holographic Spatial-Spectral Imaging”

Principal Investigator: Raymond Kostuk (Barton Co-investigator)

Type: Research Grant 08/25/06-07/31/08

Agency: National Institutes of Health/ NCI R21 CA118167

Total Direct Costs: $154,400 Effort 7%

This grant funds development of an imaging system capable of simultaneously obtaining three spatial and one spectral dimensions.

“Dual-modality system for imaging colon cancer in mice”

Principal Investigator: Jennifer Barton

Type: Research Grant 07/01/04-06/30/09

Agency: National Institutes of Health/NCI R01 CA109835

Total Direct Costs $1,126,022 Effort 20%

This grant funds development of a dual modality imaging system (optical coherence tomography and fluorescence spectroscopy) and the application of this system to minimally invasive imaging of mouse colon cancer models.

“Chemoprevention of Skin Cancer”

Principal Investigator: David Alberts (Barton investigator)

Type: Program Project Grant 07/01/04-06/30/09

Agency: National Institutes of Health/NCI P01 CA27502

Total Direct Costs: $14,403,950 Effort: 2%

Barton’s role in the grant is to develop optical coherence tomography as a non-invasive biomarker for skin sundamage and chemopreventive agent efficacy.

“Contrast Agents for Optical Coherence Tomography” (Past)

Principal Investigator: Marek Romanowski (Barton Co-investigator)

Type: Research Grant 07/01/04-06/30/07

Agency: Arizona Disease Control and Research Commission/ 9-002

Total Direct Costs: $250,000 Effort: 5%

This grant funds creation of liposome-scaffold, gold nanoparticles for OCT imaging contrast.

“Imaging the Vascular Response to Implants” (Past)

Principal Investigator: Jennifer Barton

Type: Independent Scientist Award 07/01/02-06/30/07

Agency: National Institutes of Health/NIBIB K02 EB000163

Total direct costs: $448,250 Effort 75%

This independent scientist award provides salary support and relief from some teaching/service activities, so that more time can be spent on research.

“A three dimensional in vivo system for measuring gene expression” (Past)

Principal Investigator: June Medford, Colorado State Univeristy

Agency: National Science Foundation MCB-0236683

Type: Research Grant, 06/01/03-05/31/05

Total direct costs for UA subcontract: $4000 Effort 4%

Barton is co-PI on this grant to build an optical coherence microscope and use it for imaging gene expression in Arabidopsis.

“Parallel Optical Coherence Tomography for Endoscopic Imaging” (Past)

Principal Investigator: Jennifer Barton

Type: Research Grant 10/01/02-03/31/07

Agency: National Institutes of Health/NIBIB R01 EB01032

Total Direct Costs $690,642 Effort 25%

This project fund development of a novel, parallel-imaging OCT system, using arrays of superluminescent diodes, detectors, and CMOS processing channels. Feasibility will be tested by imaging the bladders of rabbits and humans.

“Southwest Small Animal Imaging Resource” (Past)

Co-Principal Investigator: Jennifer K. Barton

Agency: National Institutes of Health, CA83148

Type: Small Animal Imaging Resource, 10/01/99 - 09/30/04

Total direct costs: $ 4,215,093 Effort: 25%

The PI on this grant is Robert J. Gillies. Dr. Barton's involvement is to build an OCT system specifically for small animal imaging.

“Optical Imaging and Spectroscopy of Mouse GI tissue” (Past)

Principal Investigator: Jennifer Barton

Type: Pilot Project in Cancer Research 07/01/02-03/31/04

Agency: National Institutes of Health/NCI

Total direct costs: $56,000 Effort: 10 %

This grant was awarded through the University of Arizona Cancer Center SPORE in GI Cancers (Eugene Gerner PI), and provides support to perform initial studies of OCT and spectroscopy of mouse gastrointestinal tissues.

“Imaging the Healing Response of Glaucoma Implants” (Past)

Principal Investigator: Jennifer K. Barton

Agency: Whitaker Foundation

Type: Research Grant, 12/01/00-11/30/03 ncx 5/31/04

Total direct costs: $176,220 Effort: 20%

This grant is for development of optical probes and signal processing techniques to evaluate the healing response of three types of implants to treat end-stage glaucoma.

"Vascular Imaging with Optical Low-Coherence Techniques" (Past)

Principal Investigator: Jennifer K. Barton

Agency: National Science Foundation

Type: Research Grant, 9/01/99 – 8/31/02 ncx 8/31/03

Total direct costs: $185,923 Effort: 17%

This grant is for development of hardware and software to perform imaging and characterization of the

vascular system with OCT and other low coherence techniques.

Classes Taught:

BME 417/517 Measurement and Data Analysis in Biomedical Engineering

ECE 340 Engineering Systems Analysis

ECE 4/529 Digital Signal Processing

OPTI/BME 630 Biomedical Imaging and Biophotonics

Students Graduated:

2000 Kristi Hansen, M.S. Biomedical Engineering (Engineer, Sebra, Tucson, AZ)

2001 Xianfeng Li, M.S. Electrical Engineering (Software Engineer, Kronos, Inc., Beaverton, OR)

2003 Alexandre Tumlinson, M.S. Optical Sciences (Ph.D. student in BME, U. Arizona)

2003 Steven Stromski, M.S. Optical Sciences (Engineer, Envisioneering, Inc., VA)

2003 Ajay Jain, M.S. Electrical Engineering (Conexant Systems, Hyderabad, India)

2004 Kirk Gossage, Ph.D. Biomedical Engineering, “Optical Coherence Tomography and Texture Analysis: Non-Invasive Monitoring of Tissue Response to Glaucoma Implant” (Staff Scientist, Cambridge Research & Instrumentation, Inc., Woburn, MA)

2005 Elizabeth Kanter, M.S. Biomedical Engineering (Ph.D. student, Vanderbilt U.)

2005 James McNally, M.S. Optical Sciences (Engineer, Boston Scientific, Natick, MA)

2006 Wei Xu, Ph.D. Systems and Industrial Engineering, “Analog Signal Processing for Optical Coherence Imaging Systems” (Engineer, Texas Instruments Inc., Tucson, AZ)

2007 Lida Hariri, Ph.D. Biomedical Engineering, “Optical Coherence Tomography and Laser Induced Fluorescence in Mouse Models of Colorectal Cancer” (Continuing as Medical Student in MD/PhD program, The University of Arizona)

2007 Alexandre Tumlinson, Ph.D. Biomedical Engineering, “Ultrahigh-resolution endoscopic optical coherence tomography for in vivo mouse colonoscopy” (Post-doctoral Associate, Cardiff University)

Student Awards:

2001 Kirk Gossage, Arizona Graduate Imaging Fellowship

2001 Jonathan Alberding, NIH Predoctoral Fellowship for Students with Disabilities (co-sponsor)

2003 Alexandre Tumlinson, Arizona Graduate Imaging Fellowship

2004 Alexandre Tumlinson, Fulbright Comprehensive Grant (to University of Vienna)

2004 Garret Bonnema, Christopher Karl Schultz Memorial Scholarship

2005 James McNally, Arizona Graduate Imaging Fellowship

2005 Ross Walker, Outstanding Electrical Engineering Senior of the Class

2005 Ross Walker, International Engineering Consortium Award

2006, 2007 Amy Winkler, Achievement Rewards for College Scientists (ARCS) Fellowship

2006 Lida Hariri, P.E.O. Scholar Award

2006 Lida Hariri, Arizona Graduate Imaging Fellowship

2007 Vrushali Korde, SPIE Scholarship Award in Optical Science and Engineering

2007 Varun Bhartia, Outstanding College of Engineering Senior